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The principal cytochrome P450 isoenzyme involved appears to generally be CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. Somewhere around eighty five% of an oral dose seems while in the urine in 24 hrs of administration, most as being the glucuronide conjugate, with little quantities of other conjugates and unchanged drug (see OVERDOSAGE)